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Die Effekte werden der Hemmung der Carnitinbiosynthese durch Inhibition des Enzyms γ-Butyrobetain-Hydroxylase zugeschrieben. Another review concurred with these data, but noted that individual patients have been identified who experienced significant decreases in plasma concentrations of combined OC components and who appeared to ovulate; the agents most often associated with these changes were rifampin, tetracyclines, and penicillin derivatives.

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